Document Type : Original Article
Authors
1
Applied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical sciences, Tehran, Iran.
2
Department of Pharmacognosy and Traditional Pharmacy, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
3
Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.
4
Department of Anatomical Sciences, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
5
Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
10.30491/tm.2025.527334.1844
Abstract
Introduction: Ulcerative colitis (UC) is a common inflammatory bowel disease that presents significant therapeutic challenges, including adverse drug effects and high treatment costs. Natural-derived agents, such as herbal products, may provide new treatment avenues. This study evaluated the effects of Baneh gum extract (BGE) on immunologic and histopathologic changes in an experimental UC model.
Method: UC was induced using acetic acid in BALB/c mice. Forty mice were randomly divided into four groups (n = 10): the first group served as a control (no treatment); the second and third groups received BGE before (pre-BGE) and after (post-BGE) disease induction, respectively; and the fourth group received mesalazine. After 10 days, the mice were euthanized, and the levels of inflammatory biomarkers, including myeloperoxidase (MPO), nitric oxide, interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), were measured. In addition, histopathologic examinations were performed according to standard protocols.
Result: Our results showed that BGE significantly reduced the production of mediators and inflammatory cytokines, including myeloperoxidase, nitric oxide, IL-1, IL-6, and TNF-α, in an experimental mouse model of acetic acid-induced UC. Histopathological changes were also significantly alleviated by BGE in this model.
Conclusion: Our findings support the beneficial use of BGE by attenuating the histopathological and immunological perturbations induced by this experimental animal model of UC. The study highlights the therapeutic promise of BGE, a natural product, in reducing inflammation and tissue damage associated with UC. Further research is needed to establish its clinical efficacy and safety in human patients.
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