Document Type : Original Article
Authors
1
Associate Professor Associate Professor of Critical Care Medicine Department of Anesthesiology, School of Medicine Shahid Bahonar Hospital Kerman University of Medical
2
Assistant Professor of Clinical Toxicology Department of Emergency Medicine, School of Medicine Afzalipour Hospital, Shahid Bahonar Hospital Kerman
3
Department of Emergency Medicine, School of Medicine, Afzalipour Hospital, Shahid Bahonar Hospital, Kerman University of Medical Sciences, Kerman, Iran
4
Professor of Biostatistics, Department of Epidemiology and Biostatistics, School of Public Health, Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
5
General Practitioner, Qom University of Medical Sciences, Qom, Iran
Abstract
Introduction: There are various approaches to fluid therapy for patients with lung contusions, and managing fluid levels can be crucial to the recovery of these patients. This study was conducted from January to June 2022 to determine the effectiveness of two methods of fluid therapy with and without Lasix in patients with crash injury accompanied by lung contusion.
Methods: This clinical trial, conducted at Bahonar Hospital, Kerman, randomly divided patients with crush injury into two groups: recipients of normal saline and recipients of crystalloid plus Lasix. Clinical parameters, including blood pressure, respiratory function, and biochemical markers, were monitored at baseline and every 3 hours for a period of 96 hours.
Results: The Lasix group showed a significantly reduced need for intubation (22.2% vs 43.8%, p = 0.02) and shorter NIV duration (p = 0.008) compared to the control group. Intra-abdominal pressure and PF ratio demonstrated favorable trends in the intervention group (p<0.01). Significant improvements in CPK, phosphorus, and potassium levels were observed with diuretic therapy (p<0.05).
Conclusion: The addition of Lasix to standard fluid therapy improved respiratory outcomes and metabolic parameters in patients with crush injuries and pulmonary contusions. This combined approach warrants further investigation in larger clinical trials.
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