Evaluating Desmopressin Spray for Surgical Wound Drainage in Femoral Surgery Patients in Taleghani Hospital

Mehrvar, Amir; Ahmadi Abdashti, Ahmadreza; Ehsani, Akbar; Heydari, Samareh; Emami Meybodi, Mohammad Kazem; Zandi, Reza

doi:10.30491/tm.2024.457307.1733

Evaluating Desmopressin Spray for Surgical Wound Drainage in Femoral Surgery Patients in Taleghani Hospital

Document Type : Original Article

Authors

Amir Mehrvar ¹

Ahmadreza Ahmadi Abdashti ²

Akbar Ehsani ²

Samareh Heydari ³

Mohammad Kazem Emami Meybodi ⁴

Reza Zandi ⁵

¹ Assistant professor of Department of Orthopedics, Taleghani Hospital Research Development committee, Medical school, Shahid Beheshti University of medical sciences, Tehran, Iran.

² Resident of Orthopedic Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

³ Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.

⁴ Trauma Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

⁵ Associate professor of Musculoskeletal Injuries Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

10.30491/tm.2024.457307.1733

Abstract

Introduction: Prolonged wound drainage (PWD) increases the risk of infection by compromising the skin barrier and promoting bacterial growth. Desmopressin, known for its hemostatic properties, has demonstrated the potential to reduce bleeding and accelerate wound healing in various surgical procedures.
Methods: In study, 50 patients aged between 18 and 65 undergoing total joint arthroplasty and any femoral fractures were divided into intervention and control groups. Desmopressin spray with a daily dose of 80 micrograms for two days was prescribed for the intervention group. Wound discharge volume, hospitalization, and postoperative complications were compared between the two groups.
Results: There was a notable reduction (P=0.016) in discharge volume observed within both the control (14.4 ± 14.3 milliliters) and desmopressin-administered (6.5 ± 7.8 milliliters) groups on the second day postoperative. Also, discharge volume decreased significantly in both groups (p<0.001), and a significant discrepancy emerged in the efficacy of discharge reduction between the two groups (p<0.001). However, hospitalization was significantly (P=0.008) lower in the intervention group (3.64 ± 2.51 days) than in the control group (6.36 ± 3.1 days).
Conclusion: Patients receiving desmopressin exhibited significantly reduced discharge and shorter hospitalization periods than controls.

Keywords

Desmopressin

Prolonged Wound Drainage

Femoral Fractures

Total Joint Arthroplasty

Subjects