Introduction: Exosomes stimulate tissue regeneration and can be a substitute customary therapies of wound healing. The study aimed to compare the wound healing effects of exosome derived from Mesenchymal Stem Cells (MSCs) and other cells in wounds.
Methods: We searched PubMed, MEDLINE, EMBASE, International Clinical Trials Registry Platform, Clinical Trials, Cochrane Library, Wiley, Google Scholar, ISI Web of Knowledge, and Scopus study design, study location, various types of cell origin, and the healing outcome of extracted exosome. Two reviewer authors independently investigated and assessed the titles and abstracts of all articles; the third reviewer determined disagreement between them. Data were documented about study design, study location, various types of cell origin, and the healing outcome of extracted exosome.
Results: A total of 2896 records were choice in an initial search for studies that used exosome for wound healing. Ultimately, 13 studies (seven articles applied MSC as origin of exosome, six studies used other cells expect MSCs as origin of exosome for wound healing) were included in this study. These articles were published from 2001 to December, 2023. This review study showed that MSC-derived exosomes have more wound-healing effects in angiogenesis, proliferation, collagen synthesis, and re-epithelialization. On the other hand, exosome with different cell origin has more wound-healing effects, such as proliferation, re-epithelialization, angiogenesis, and collagen synthesis.
Conclusion: Both MSC-derived exosomes and exosome with different cell origin, have great effects on the wound healing process. But, MSC-derived exosomes have better effects on the wounds that need to more angiogenesis and cell proliferation. Also, exosomes with different cell origin can have better effects on the wounds with more requirement of cell proliferation, and re-epithelialization.