Comparison of Burn Treatment with Nano Silver-Aloe Vera Combination and Silver Sulfadiazine in Animal Models

Document Type : Original Article


1 Department of Pediatric Surgery, Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran

2 Department of Community Medicine, Mazandaran University of Medical Sciences, Sari, Iran

3 Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran

4 Department of Infectious Disease, Zareh Hospital, Mazandaran University of Medical Sciences, Sari, Iran

5 Department of Pathology, Islamic Azad University, Sari, Iran

6 Department of Anesthesiology, Traditional and Complementary Medicine Research Centre, Mazandaran University of Medical Sciences, Sari, Iran

7 Brain and Mind Centre, Sydney Medical School, University of Sydney, Australia



Background: Silver sulfadiazine cream is used extensively for burns, nonetheless, several adverse reactions and side effects are presented in multiple cases. The aim of this study was to compare the healing effect of nano silver-aloe vera composition and silver sulfadiazine on burns in experimental rat models.
Objectives: The experimental studywas performed on15male Sprague-Dawley rats to compare the burn treatmentwith nano silveraloe vera combination and silver sulfadiazine in the animal laboratory.
Methods: Two deep second degree burns on both sides of the abdomen were created. One side was covered by cream and the other by 1% silver sulfadiazine. Response to treatment was assessed by digital photography on day 28. Histological parameters, such as angiogenesis, fibrosis, epithelialization, and inflammatory reactions, were evaluated.
Results: The average burn size in the nano silver aloe vera group was significantly lower compared to the average burn size of the silver sulfadiazine group (P < 0.05). Upon pathologic assessment, the re-epithelialization of the epidermis on the fourteenth day in the nano silver group was significantly higher. In addition, this difference in terms of fibrosis and angiogenesis was observed on the fourteenth day and it was higher in the nano silver group (P < 0.05).
Conclusions: The use of nano silver compounds in combination with aloe vera compared to silver sulfadiazine cream can expedite re-epithelialization and wound healing in rats.