Background: Burns are one of the major public health problems worldwide, particularly in the developing countries. The proper treatment of burns can reduce the complications of the injury. Objectives: The current study assessed the effects of silver sulfadiazine (SSD) and Adibderm® herbal ointments to treat patients with second degree burns. Methods: In the current randomized clinical trial, 60 adult patients (ranged 18 - 65 years old) with second-degree burns and 1% - 10% burns in the extremities and trunk areas referred to Tabriz Sina hospital were enrolled. Patients were divided into 2 groups (group A, SSD ointment; and group B, Adibderm® herbal ointment). The study was conducted after obtaining written informed consent from the patients. Patients were followed up daily until the end of treatment. Healing time (days), treatment satisfaction, and complications were compared between the 2 groups. Results: There was no significant difference between the 2 groups in terms of demographic variables (P value > 0.05). The mean of healing time in groups A and B were 11.83 ± 2.32 and 7.53 ± 2.28 days, respectively (P < 0.0001). The mean of treatment satisfaction in groups A and B were 7.23 ± 1.19 and 7.83 ± 1.02 days, respectively (P < 0.041). In SSD ointment group, 1 (3.3%) patient had wound infection and 7 (23.3%) patients in Adibderm® herbal ointment group had wound irritation caused by the ointment. Conclusions: Based on the current study results, Adibderm® herbal ointment was superior to SSD ointment in terms of healing time and treatment satisfaction.