Background: Adaptive support ventilation (ASV) is one of the advanced modes of ventilation. The available evidence regarding the process of tracheal extubation indicates that staff working in intensive care unit usually performs the weaning process according to their own experiences and conventional methods. Objectives: This study aimed to assess the effect of weaning with adaptive support ventilation in two conventional or standard methods on respiratory and hemodynamic performance indices in patients undergoing coronary artery bypass graft (CABG) surgery. Methods: In this clinical trial, 100 patients candidate for coronary artery bypass graft (CABG) surgery at Jamaran hospital were allocated to experimental and control groups in 2015. Each group had patients. The conventional method of ASV was used in the control group without any intervention, while the standard method of ASV was applied in the experimental group. The groups were compared in terms of arterial blood gases, vital signs, atelectasis, and duration of weaning process. Results: There was no statistically significant difference between the experimental and control groups in terms of demographic variables and disease history. Also, duration of mechanical ventilation and weaning process, duration of the patient’s trigger to the tracheal extubation as well as other respiratory performance indicators and vital signs were similar between the groups (P > 0.05). Conclusions: The results of this study indicate that in stable patients who have no history of lung problems, there is no need to apply the difficult weaning protocol. These patients can be weaned without any complication.