The Effect of Dexmedetomidine on Blood Pressure in Patients With Hypertension After Emergency Laparotomy for Trauma: A Randomized, Double-blind, Clinical Trial

Document Type : Original Article


1 Associated Professor of Anesthesia, Paramedical Faculty, Tabriz University of Medical Sciences,Tabriz, Iran

2 Associated Professor of Anesthesia, Medical Faculty, Tabriz University of Medical Sciences,Tabriz, Iran



Introduction: Patients with a history of hypertension experience higher postoperative complications than healthy individuals. The frequency of such complications is also higher in emergency patients than elective ones; therefore, it seems that preventive measures are essential. The present study aimed at determining the effect of dexmedetomidine on blood pressure in patients with hypertension after emergency laparotomy for trauma.
Methods: The present study was a randomized, double-blind, clinical trial performed from 2019 to 2020 on patients with a history of hypertension undergoing emergency laparotomy. Patients received the intervention 15 minutes before surgery (the intervention group: intravenous (iv) dexmedetomidine and the control group: normal saline), and the intensity of pain, agitation, and blood pressure were measured and compared at different time points. Data were compared in SPSS version 21 using t-test and Chi-square tests considering a significance level of <0.05.
Results: There were statistically significant differences between the two groups just after the drug infusion and at all studied time points (P <0.05) so that the intervention group had more stable blood pressure. Pain intensity (P <0.05) and the degree of agitation (p <0.05) were significantly lower in the intervention group than in the control group at all studied time points.
Conclusion: Dexmedetomidine infusion decreased blood pressure, pain intensity, and agitation in patients with a history of hypertension undergoing emergency laparotomy for trauma.


Articles in Press, Corrected Proof
Available Online from 30 March 2021
  • Receive Date: 23 February 2021
  • Revise Date: 28 February 2021
  • Accept Date: 30 March 2021