TY - JOUR ID - 128635 TI - Effect of Dexmedetomidine on Blood Pressure in Hypertension Patients after Emergency Laparotomy for Trauma: A Randomized Double-blind Clinical Trial JO - Trauma Monthly JA - TM LA - en SN - 2251-7464 AU - Movassaghi Gargari, Reza AU - Mohammadipour Anvari, Hassan AD - Associate Professor of Anesthesia, Medical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran AD - Associate Professor of Anesthesia, Paramedical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran Y1 - 2021 PY - 2021 VL - 26 IS - 2 SP - 94 EP - 99 KW - Emergency Laparotomy KW - Trauma KW - blood pressure KW - dexmedetomidine DO - 10.30491/tm.2021.274843.1249 N2 - Background: Patients with a history of hypertension experience higher postoperative complications than healthy individuals. The frequency of such complications is also higher in emergency patients than elective ones; therefore, it seems that preventive measures are essential. Objectives: The present study aimed at determining the effect of dexmedetomidine on blood pressure in patients with hypertension after emergency laparotomy for trauma. Methods: The present study was a randomized, double-blind clinical trial performed from 2019 to 2020 on patients with a history of hypertension undergoing emergency laparotomy. Patients received the intervention 15 minutes before surgery (the intervention group: intravenous (iv) dexmedetomidine and the control group: normal saline), and the intensity of the pain(VAS), agitation(RASS), and blood pressure were measured and compared at different time points. Data were compared using SPSS software (version 21) by t-test and Chi-square tests considering a significance level of <0.05. Results: There were statistically significant differences between the two groups just after the drug infusion and at all studied time points (p <0.05), so that the intervention group had more stable blood pressure. Pain intensity (p <0.05) and the degree of agitation (p <0.05) in the intervention group were significantly lower than that in the control group at all studied time points. Conclusion: Dexmedetomidine infusion leads to a stabilization of blood pressure during surgery and after surgery, pain relief, and agitation in patients with hypertension undergoing emergency laparotomy for trauma. UR - https://www.traumamon.com/article_128635.html L1 - https://www.traumamon.com/article_128635_6f953b12cfe8eacb313bde075f074066.pdf ER -