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<Article>
<Journal>
				<PublisherName>Official Publication of the National Center for Trauma Research</PublisherName>
				<JournalTitle>Trauma Monthly</JournalTitle>
				<Issn>2251-7464</Issn>
				<Volume>30</Volume>
				<Issue>2</Issue>
				<PubDate PubStatus="epublish">
					<Year>2025</Year>
					<Month>04</Month>
					<Day>01</Day>
				</PubDate>
			</Journal>
<ArticleTitle>Designing an Empowerment Service Management Model for People with Disability under the Welfare Organization of Iran</ArticleTitle>
<VernacularTitle></VernacularTitle>
			<FirstPage>1372</FirstPage>
			<LastPage>1380</LastPage>
			<ELocationID EIdType="pii">225115</ELocationID>
			
<ELocationID EIdType="doi">10.30491/tm.2024.460042.1739</ELocationID>
			
			<Language>EN</Language>
<AuthorList>
<Author>
					<FirstName>Zahra</FirstName>
					<LastName>Ebrahim</LastName>
<Affiliation>PhD Student, Department of Health Services Administration, SR.C, Islamic Azad University, Tehran, Iran.</Affiliation>
<Identifier Source="ORCID">0000-0003-4064-6132</Identifier>

</Author>
<Author>
					<FirstName>Leila</FirstName>
					<LastName>Riahi</LastName>
<Affiliation>Associate Professor, Department of Health Services Administration, SR.C, Islamic Azad University, Tehran, Iran.</Affiliation>
<Identifier Source="ORCID">0000-0002-2044-5600</Identifier>

</Author>
<Author>
					<FirstName>Kamran</FirstName>
					<LastName>Hajinabi</LastName>
<Affiliation>Assistant Professor, Department of Health Services Administration, SR.C, Islamic Azad University, Tehran, Iran.</Affiliation>
<Identifier Source="ORCID">0000-0003-1227-7106</Identifier>

</Author>
<Author>
					<FirstName>Leila</FirstName>
					<LastName>Nazarimanesh</LastName>
<Affiliation>Assistant Professor, Department of Health Services Administration, SR.C, Islamic Azad University, Tehran, Iran.</Affiliation>
<Identifier Source="ORCID">0000-0003-0713-7942</Identifier>

</Author>
</AuthorList>
				<PublicationType>Journal Article</PublicationType>
			<History>
				<PubDate PubStatus="received">
					<Year>2024</Year>
					<Month>05</Month>
					<Day>28</Day>
				</PubDate>
			</History>
		<Abstract>&lt;strong&gt;Introduction: &lt;/strong&gt;This research has focused on designing the empowerment service management model for people with disabilities covered by Iran&#039;s Welfare Organization.&lt;br /&gt;&lt;strong&gt;Methods:&lt;/strong&gt; The research&#039;s statistical population included experts and professionals who provide empowerment services for people with disabilities in the country&#039;s welfare organization. Due to the heterogeneous population, whose distribution varied across groups and classes, the probability sampling method with classification was employed. The validity and reliability of the research tool were checked by face validity and content validity. To assess reliability, Cronbach&#039;s alpha was used, yielding a value of 0.974.&lt;br /&gt;&lt;strong&gt;Results:&lt;/strong&gt; The data were analyzed using structural equation modeling via the covariance method with AMOS 24 software. According to the findings, the proposed model comprises 34 items and six factors: planning, financial resources, resource generation, employment, coordination, and control. &lt;br /&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt; The results showed that the present study could fill the gap resulting from the lack of suitable models in the field under investigation. It is one of the first efforts in designing and providing an empowerment service management model to support the disabled in Iran, contributing to the enrichment of the research literature.</Abstract>
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			<Param Name="value">Management</Param>
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			<Param Name="value">Modeling</Param>
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			<Param Name="value">Disabled</Param>
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			<Param Name="value">Welfare Organization</Param>
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<Article>
<Journal>
				<PublisherName>Official Publication of the National Center for Trauma Research</PublisherName>
				<JournalTitle>Trauma Monthly</JournalTitle>
				<Issn>2251-7464</Issn>
				<Volume>30</Volume>
				<Issue>2</Issue>
				<PubDate PubStatus="epublish">
					<Year>2025</Year>
					<Month>04</Month>
					<Day>01</Day>
				</PubDate>
			</Journal>
<ArticleTitle>Investigating the Relationship between Occupational Stress and Marital Satisfaction in Emergency Medical Technicians in 2023: A Cross-sectional Study</ArticleTitle>
<VernacularTitle></VernacularTitle>
			<FirstPage>1381</FirstPage>
			<LastPage>1387</LastPage>
			<ELocationID EIdType="pii">225122</ELocationID>
			
<ELocationID EIdType="doi">10.30491/tm.2024.446144.1702</ELocationID>
			
			<Language>EN</Language>
<AuthorList>
<Author>
					<FirstName>Hamidreza</FirstName>
					<LastName>Zeraatkhah</LastName>
<Affiliation>PhD student of Nursing, Trauma Nursing Research Center, Kashan University of Medical Sciences, Kashan, Iran. http://orcid.org/0009-0004-3154-7559</Affiliation>

</Author>
<Author>
					<FirstName>Jafar</FirstName>
					<LastName>Shahbazpour</LastName>
<Affiliation>Department of Medical Surgical Nursing, School of Nursing, Qom University of Medical Sciences, Qom, IR Iran. https://orcid.org/0000-0002-6103-2765</Affiliation>
<Identifier Source="ORCID">0000-0002-6103-2765</Identifier>

</Author>
<Author>
					<FirstName>Abed</FirstName>
					<LastName>Asgari</LastName>
<Affiliation>Internal Surgery Department, School of Nursing, Qom University of Medical Sciences, Qom, IR Iran. https://orcid.org/0000-0002-8645-6353</Affiliation>
<Identifier Source="ORCID">0000-0002-8645-6353</Identifier>

</Author>
<Author>
					<FirstName>Leila</FirstName>
					<LastName>Ghanbari-afra</LastName>
<Affiliation>Assistant professor, Department of Medical Surgical Nursing, Faculty of Nursing, Qom University of Medical Sciences, Qom, IR Iran. https://orcid.org/0000-0003-3044-9063</Affiliation>
<Identifier Source="ORCID">0000-0003-3044-9063</Identifier>

</Author>
</AuthorList>
				<PublicationType>Journal Article</PublicationType>
			<History>
				<PubDate PubStatus="received">
					<Year>2024</Year>
					<Month>02</Month>
					<Day>28</Day>
				</PubDate>
			</History>
		<Abstract>&lt;strong&gt;Introduction: &lt;/strong&gt;Work and family life are two fundamental components of people&#039;s lives, each of which affects the other. This study aimed to investigate the relationship between occupational stress and marital satisfaction in Emergency Medical Technicians.
&lt;strong&gt;Method: &lt;/strong&gt;In this study, 200 Emergency Medical Technicians were selected by a stratified cluster method (2023). Data were collected using the Persian version of the Occupational Stress and ENRICH marital satisfaction questionnaires.
&lt;strong&gt;Results:&lt;/strong&gt; The average scores for Occupational stress and marital satisfaction were 112.48±13.38 and 145.94±22.21, respectively. Occupational stress exhibited a significant negative correlation with marital satisfaction (r = -0.592, p = 0.028). Education level, employment status, work experience, having a second job, and occupational stress explained 78% of the variance in marital satisfaction among Emergency Medical Technicians (R = 0.784, R² = 0.614, p = 0.001).
&lt;strong&gt;Discussion:&lt;/strong&gt; Reducing occupational stress can improve marital satisfaction among Emergency Medical Technicians.
&lt;strong&gt;Implications for Practice&lt;/strong&gt;&lt;strong&gt;: &lt;/strong&gt;Selecting students interested in the pre-hospital profession can help foster a positive work environment among employees. Additionally, pre-hospital managers should pay attention to the factors affecting Occupational stress and marital satisfaction to improve the quality of services provided by Emergency Medical Technicians.</Abstract>
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			<Param Name="value">marital satisfaction</Param>
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			<Object Type="keyword">
			<Param Name="value">Emergency Medical Technicians</Param>
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			<Object Type="keyword">
			<Param Name="value">Iran</Param>
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</Article>

<Article>
<Journal>
				<PublisherName>Official Publication of the National Center for Trauma Research</PublisherName>
				<JournalTitle>Trauma Monthly</JournalTitle>
				<Issn>2251-7464</Issn>
				<Volume>30</Volume>
				<Issue>2</Issue>
				<PubDate PubStatus="epublish">
					<Year>2025</Year>
					<Month>04</Month>
					<Day>01</Day>
				</PubDate>
			</Journal>
<ArticleTitle>Conceptual Model of Hospital Preparedness in Response to Disasters An Integrated Review Study</ArticleTitle>
<VernacularTitle></VernacularTitle>
			<FirstPage>1388</FirstPage>
			<LastPage>1402</LastPage>
			<ELocationID EIdType="pii">225124</ELocationID>
			
<ELocationID EIdType="doi">10.30491/tm.2024.452366.1720</ELocationID>
			
			<Language>EN</Language>
<AuthorList>
<Author>
					<FirstName>Ehsan</FirstName>
					<LastName>Abadi</LastName>
<Affiliation>Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, IR Iran</Affiliation>
<Identifier Source="ORCID">0000-0002-9659-1145</Identifier>

</Author>
<Author>
					<FirstName>Ali</FirstName>
					<LastName>Rahmani</LastName>
<Affiliation>Nursing Care Research Center, Clinical Sciences Institute, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, IR Iran</Affiliation>
<Identifier Source="ORCID">0000-0003-0323-3857</Identifier>

</Author>
<Author>
					<FirstName>Abdollah</FirstName>
					<LastName>Sagahfi</LastName>
<Affiliation>Nursing Care Research Center, Clinical Sciences Institute, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, IR Iran</Affiliation>

</Author>
<Author>
					<FirstName>Mehdi</FirstName>
					<LastName>Jafari Oori</LastName>
<Affiliation>Nursing Care Research Center, Clinical Sciences Institute, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran</Affiliation>
<Identifier Source="ORCID">0000-0002-7788-7063</Identifier>

</Author>
<Author>
					<FirstName>Hosein</FirstName>
					<LastName>Mahmoudi</LastName>
<Affiliation>PhD, Professor in Nursing Education, Nursing Care Research Center, Clinical Science Institute Center, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, IR Iran</Affiliation>
<Identifier Source="ORCID">0000-0003-4586-3486</Identifier>

</Author>
<Author>
					<FirstName>Javad</FirstName>
					<LastName>Shojafard</LastName>
<Affiliation>Health in Emergency and Disaster Research Center, Social Health Research Institute, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran</Affiliation>

</Author>
</AuthorList>
				<PublicationType>Journal Article</PublicationType>
			<History>
				<PubDate PubStatus="received">
					<Year>2024</Year>
					<Month>04</Month>
					<Day>13</Day>
				</PubDate>
			</History>
		<Abstract>&lt;strong&gt;Introduction: &lt;/strong&gt;The term &quot;Disaster&quot; refers to an unexpected and undesirable event. Healthcare facilities face a range of challenges, varying in both nature and severity. To effectively manage such critical situations, healthcare centers need to have well-defined guidelines and protocols in place.This integrative review aims to create a comprehensive conceptual framework that outlines hospital preparedness during Disasters.&lt;br /&gt;&lt;strong&gt;Methods:&lt;/strong&gt; This study employed an integrative review design, following Whittemore&#039;s five-stage framework: problem identification, literature search, data evaluation, data analysis, and data presentation. The search terms included &quot;disaster preparedness,&quot; &quot;crisis,&quot; &quot;emergency response,&quot; and &quot;hospital preparedness.&quot; Databases searched were PubMed, Scopus, Web of Science, and others, covering literature from January 1993 to August 2021. Studies in English or Persian, including quantitative, qualitative, and mixed methods, were included. Methodological quality was assessed using specific tools for each study type, and all included studies were rated as high quality.&lt;br /&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study involved a thematic analysis of 25 articles, including 21 quantitative studies, two qualitative studies, and two mixed-method studies. From this analysis, the central theme of Hospital Preparedness in Response to Disaster emerged. The key concepts related to this theme were systematically examined and categorized into four principal groups: Command and Control, Management of Support and Procurement, Communications, and Ethical and Legal Considerations. These groups represent the essential components necessary for effective crisis management within healthcare institutions.&lt;br /&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt;&lt;strong&gt; &lt;/strong&gt;Hospitals must be prepared for Disasters.  The results of our study suggest a comprehensive model that focuses on Command and Control, Support and Procurement Management, Communications, and Ethical and Legal aspects. Further research is necessary to identify practical solutions for various crisis scenarios and enhance hospital preparedness.</Abstract>
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			<Param Name="value">Models</Param>
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<Article>
<Journal>
				<PublisherName>Official Publication of the National Center for Trauma Research</PublisherName>
				<JournalTitle>Trauma Monthly</JournalTitle>
				<Issn>2251-7464</Issn>
				<Volume>30</Volume>
				<Issue>2</Issue>
				<PubDate PubStatus="epublish">
					<Year>2025</Year>
					<Month>04</Month>
					<Day>01</Day>
				</PubDate>
			</Journal>
<ArticleTitle>An Overview Study on Pain Management in Trauma and Critical Care Patients</ArticleTitle>
<VernacularTitle></VernacularTitle>
			<FirstPage>1403</FirstPage>
			<LastPage>1410</LastPage>
			<ELocationID EIdType="pii">213671</ELocationID>
			
<ELocationID EIdType="doi">10.30491/tm.2025.498740.1801</ELocationID>
			
			<Language>EN</Language>
<AuthorList>
<Author>
					<FirstName>Seyed Mohammadreza</FirstName>
					<LastName>Amouzegar Zavareh</LastName>
<Affiliation>Atherosclerosis research center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran</Affiliation>
<Identifier Source="ORCID">0000-0002-3587-6040</Identifier>

</Author>
<Author>
					<FirstName>Masoud</FirstName>
					<LastName>Latifi-Pour</LastName>
<Affiliation>Chemical Injuries Research Center and Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran</Affiliation>

</Author>
</AuthorList>
				<PublicationType>Journal Article</PublicationType>
			<History>
				<PubDate PubStatus="received">
					<Year>2025</Year>
					<Month>01</Month>
					<Day>08</Day>
				</PubDate>
			</History>
		<Abstract>&lt;strong&gt;Introduction: &lt;/strong&gt;Almost all injured patients endure significant pain. Addressing this pain is essential for their recovery and overall well-being. There are numerous effective pain management options for patients. The primary goal of this study is to comprehensively outline pain management options for trauma and critical care patients, emphasizing helpful pharmacological interventions.
&lt;strong&gt;Methods: &lt;/strong&gt;This study involved both electronic and manual searches to identify all relevant records. The electronic search focused on published studies in English, identified through PubMed, Web of Science, Embase, and Google Scholar. We used a combination of key terms such as acute pain, critical care patients, trauma, emergency, wound, and injury.
&lt;strong&gt;Results: &lt;/strong&gt;Thorough assessment of age-specific pain management strategies to tailor care effectively. Identify the most suitable analgesics to alleviate moderate to severe pain, optimizing patient comfort. Awareness of the serious adverse effects of pain medications, carefully balancing these risks against their therapeutic benefits. Routine monitoring and reassessment of patients to continuously refine and improve their pain management regimens.
&lt;strong&gt;Conclusion:&lt;/strong&gt; By emphasizing these key considerations, we can significantly improve the quality of care for trauma patients, fostering their healing and well-being. To achieve genuinely patient-centered trauma care, it is essential to understand the obstacles to effective pain management and engage in open discussions with patients to identify solutions to overcome these barriers.</Abstract>
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			<Param Name="value">Critical Care Patients</Param>
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<Article>
<Journal>
				<PublisherName>Official Publication of the National Center for Trauma Research</PublisherName>
				<JournalTitle>Trauma Monthly</JournalTitle>
				<Issn>2251-7464</Issn>
				<Volume>30</Volume>
				<Issue>2</Issue>
				<PubDate PubStatus="epublish">
					<Year>2025</Year>
					<Month>04</Month>
					<Day>01</Day>
				</PubDate>
			</Journal>
<ArticleTitle>Study of Fall Modes and Associated Fracture Patterns in an Iranian Population</ArticleTitle>
<VernacularTitle></VernacularTitle>
			<FirstPage>1411</FirstPage>
			<LastPage>1420</LastPage>
			<ELocationID EIdType="pii">225212</ELocationID>
			
<ELocationID EIdType="doi">10.30491/tm.2024.486415.1777</ELocationID>
			
			<Language>EN</Language>
<AuthorList>
<Author>
					<FirstName>Maryam</FirstName>
					<LastName>Ameri</LastName>
<Affiliation>Department of Forensic Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran</Affiliation>
<Identifier Source="ORCID">0000-0002-9393-988X</Identifier>

</Author>
<Author>
					<FirstName>Abbas</FirstName>
					<LastName>Aghabiklooei</LastName>
<Affiliation>Department of Forensic Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran</Affiliation>

</Author>
<Author>
					<FirstName>Foroozan</FirstName>
					<LastName>Faress</LastName>
<Affiliation>Department of Forensic Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran</Affiliation>

</Author>
<Author>
					<FirstName>Amir</FirstName>
					<LastName>Ghaffari Jolfay</LastName>
<Affiliation>Rajaie Cardiovascular Institute, Tehran, Iran</Affiliation>

</Author>
<Author>
					<FirstName>Leila</FirstName>
					<LastName>Abdolkarimi</LastName>
<Affiliation>Rajaie Cardiovascular Institute, Tehran, Iran</Affiliation>

</Author>
<Author>
					<FirstName>Bahram</FirstName>
					<LastName>Bahramnejad</LastName>
<Affiliation>Department of Forensic Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran</Affiliation>
<Identifier Source="ORCID">0000-0002-3509-5703</Identifier>

</Author>
</AuthorList>
				<PublicationType>Journal Article</PublicationType>
			<History>
				<PubDate PubStatus="received">
					<Year>2024</Year>
					<Month>10</Month>
					<Day>31</Day>
				</PubDate>
			</History>
		<Abstract>&lt;strong&gt;Introduction: &lt;/strong&gt;Falls are considered to be one of the significant public health problems worldwide, and are associated with increased mortality, hospitalization, and severe fractures. Fall-related injuries lead to socio-economic impacts, including psychological distress and decreased work productivity. This retrospective study aimed to study the correlation between falling height and the frequency and types of fall fractures in accidental high falls (AHF) and intentional high falls (IHF).
&lt;strong&gt;Method:&lt;/strong&gt; The study concluded that 268 patients were hospitalized between June 1, 2011, and June 1, 2017, for the treatment of fall-related injuries. The gender, age, falling height, and fall fractures and traumas were analyzed for each individual.
&lt;strong&gt;Results:&lt;/strong&gt; The results showed that there is no significant correlation between all types of fractures and the age of individuals. Furthermore, the correlation study of the falling height and different types of fractures also illustrated that there is no significant correlation between these factors in both groups, AHF and IHF. These findings showed that the pattern of fractures can be used to distinguish AHF from IHF.
&lt;strong&gt;Conclusion:&lt;/strong&gt; Since fractures are more common in older adults, particularly in older women, it is essential to implement comprehensive injury prevention programs and facilitate the diagnosis, treatment, and rehabilitation methods for this population to minimize the overall burden.</Abstract>
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<Article>
<Journal>
				<PublisherName>Official Publication of the National Center for Trauma Research</PublisherName>
				<JournalTitle>Trauma Monthly</JournalTitle>
				<Issn>2251-7464</Issn>
				<Volume>30</Volume>
				<Issue>2</Issue>
				<PubDate PubStatus="epublish">
					<Year>2025</Year>
					<Month>04</Month>
					<Day>01</Day>
				</PubDate>
			</Journal>
<ArticleTitle>"Efforts to Master Conditions" alongside "Care in the Shadow of Fear and Stress": The Experience of Emergency Medical Technicians (EMTs)</ArticleTitle>
<VernacularTitle></VernacularTitle>
			<FirstPage>1421</FirstPage>
			<LastPage>1432</LastPage>
			<ELocationID EIdType="pii">225218</ELocationID>
			
<ELocationID EIdType="doi">10.30491/tm.2025.441794.1694</ELocationID>
			
			<Language>EN</Language>
<AuthorList>
<Author>
					<FirstName>Nasrin</FirstName>
					<LastName>Razmjoee</LastName>
<Affiliation>Student Research Committee, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran</Affiliation>
<Identifier Source="ORCID">0000-0001-6842-6911</Identifier>

</Author>
<Author>
					<FirstName>Zahra</FirstName>
					<LastName>Keshtkaran</LastName>
<Affiliation>Associate Professor, Community Based Psychiatric Care Research Center, Department of Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran</Affiliation>
<Identifier Source="ORCID">0000-0003-1723-704x</Identifier>

</Author>
<Author>
					<FirstName>Zinat</FirstName>
					<LastName>Mohebbi</LastName>
<Affiliation>Associate Professor, Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran</Affiliation>
<Identifier Source="ORCID">0000-0003-2995-0264</Identifier>

</Author>
<Author>
					<FirstName>Majid</FirstName>
					<LastName>Najafi Kalyani</LastName>
<Affiliation>Professor, Community Based Psychiatric Care Research Center, Department of Medical Emergencies, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran</Affiliation>
<Identifier Source="ORCID">0000-0002-7711-8184</Identifier>

</Author>
</AuthorList>
				<PublicationType>Journal Article</PublicationType>
			<History>
				<PubDate PubStatus="received">
					<Year>2024</Year>
					<Month>02</Month>
					<Day>05</Day>
				</PubDate>
			</History>
		<Abstract>&lt;strong&gt;Introduction: &lt;/strong&gt;Given the high prevalence of trauma and its economic and social consequences in Iran, along with the importance of the quality of initial interventions at the scene, there has been limited research conducted in Iran on the psychological and cognitive impact of individuals and their perceptions when facing life-threatening incidents, due to cultural contexts and working conditions.&lt;br /&gt;&lt;strong&gt;Methods:&lt;/strong&gt; This study employed a qualitative approach, utilizing phenomenological hermeneutics and focusing on the Van Manen methodology. The data collection method involved semi-structured in-depth interviews with EMTs, using the main research question: &quot;What is the lived experience of EMTs caring for patients with life-threatening trauma?&quot; In the first stage, deep interviews were conducted with EMTs to uncover the essence of caring for critically ill patients. In the second stage, the data collection was conducted using the Van Manen method.&lt;br /&gt;&lt;strong&gt;Results:&lt;/strong&gt; The results of this study showed that the themes of &quot;Care in the Shadow of Fear and Stress&quot; and &quot;Striving for Resilience and Mastery in Conditions&quot; emerged as fundamental aspects in the lived experience of EMTs. Based on the results of this study, &quot;Caring in the Shadow of Fear and Stress,&quot; which arises from facing traumas, indicates that technicians are overwhelmed during care and, subsequently, burdened with a multitude of pressures. On the other hand, the article highlights the effort to build resilience and mastery over circumstances, drawing on the lived experiences of emergency services personnel who provide care for patients in the shadow of fear and stress.&lt;br /&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt; The effort to build resilience and mastery over circumstances has been highlighted as another central theme in this article regarding the lived experience of EMTs caring for patients with life-threatening traumas.</Abstract>
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<Article>
<Journal>
				<PublisherName>Official Publication of the National Center for Trauma Research</PublisherName>
				<JournalTitle>Trauma Monthly</JournalTitle>
				<Issn>2251-7464</Issn>
				<Volume>30</Volume>
				<Issue>2</Issue>
				<PubDate PubStatus="epublish">
					<Year>2025</Year>
					<Month>04</Month>
					<Day>01</Day>
				</PubDate>
			</Journal>
<ArticleTitle>Identification of Targeted Therapeutic Compounds for the treatment of post-surgical adhesion: An in-Silico Study</ArticleTitle>
<VernacularTitle></VernacularTitle>
			<FirstPage>1433</FirstPage>
			<LastPage>1440</LastPage>
			<ELocationID EIdType="pii">213672</ELocationID>
			
<ELocationID EIdType="doi">10.30491/tm.2025.497075.1796</ELocationID>
			
			<Language>EN</Language>
<AuthorList>
<Author>
					<FirstName>Hamid Reza</FirstName>
					<LastName>Rasouli</LastName>
<Affiliation>Trauma Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran</Affiliation>
<Identifier Source="ORCID">0000-0003-2793-624X</Identifier>

</Author>
<Author>
					<FirstName>Moharam</FirstName>
					<LastName>Mohammadian</LastName>
<Affiliation>Trauma Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran</Affiliation>

</Author>
<Author>
					<FirstName>Seyed Mohammadreza</FirstName>
					<LastName>Amouzegar Zavareh</LastName>
<Affiliation>Atherosclerosis research center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran</Affiliation>

</Author>
<Author>
					<FirstName>Shahram</FirstName>
					<LastName>Manoochehry</LastName>
<Affiliation>Trauma Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran</Affiliation>

</Author>
<Author>
					<FirstName>Seyyed Naser</FirstName>
					<LastName>Namjoy</LastName>
<Affiliation>Trauma Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran</Affiliation>

</Author>
<Author>
					<FirstName>Samira</FirstName>
					<LastName>Talebi</LastName>
<Affiliation>Department of Medicine Genetic, National institute of genetic engineering and biotechnology, Tehran, Iran.</Affiliation>

</Author>
<Author>
					<FirstName>Fathollah</FirstName>
					<LastName>Ahmadpour</LastName>
<Affiliation>Trauma Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran</Affiliation>
<Identifier Source="ORCID">0000-0003-2984-6897</Identifier>

</Author>
</AuthorList>
				<PublicationType>Journal Article</PublicationType>
			<History>
				<PubDate PubStatus="received">
					<Year>2024</Year>
					<Month>12</Month>
					<Day>31</Day>
				</PubDate>
			</History>
		<Abstract>&lt;strong&gt;Introduction: &lt;/strong&gt;Intra-abdominal adhesions, especially intestinal adhesions and obstructions, are the most common complications after open abdominal and pelvic surgeries. Angiotensin Receptor Protein (ARB) is an essential protein involved in intestinal adhesion. This study aimed to identify new therapeutic compounds for preventing post-surgical adhesions. &lt;br /&gt;&lt;strong&gt;Methods:&lt;/strong&gt; The literature reviews identified ARBs as essential proteins in intestinal adhesion. Potential active sites for recognized target proteins were identified. The protein-ligand interaction was predicted by Molegro Virtual Docker (MVD) software. The interaction of ARBs with over 80000 drug-like compounds from the ZINC database was assessed by molecular docking. The designated compounds from the molecular docking were subjected to ADME prediction to assess drug limitations. The resulting molecules were subjected to Swiss Similarity software, and evaluation was performed using a Food and Drug Administration (FDA)- approved drugs library. Molecular dynamics (MD) simulations were performed using the GROMACS package version 2020.1 to assess the structural stability of the hit compounds. &lt;br /&gt;&lt;strong&gt;Results:&lt;/strong&gt; Four molecules, including ZINC000067920967, ZINC000161524911, ZINC000067587085, and ZINC000604511089, can block ARBs. ADME analysis demonstrated that these four molecules could be used as drugs. ADME analysis of these molecules revealed that they could be utilized as medicinal compounds. Additionally, the similarity screening against this molecule revealed that Teveten (Eprosartan), an FDA-approved drug, can be considered a therapeutic candidate for post-surgical adhesion.&lt;br /&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt; The therapeutic compounds identified in this study, which block ARBs, can be utilized for post-surgical adhesion treatment. Additionally, Eprosartan, as an FDA-approved medication, exhibits anti-adhesion effects and may be a suitable candidate for preventing intestinal adhesions after abdominal surgery. However, more studies, such as clinical trials and animal studies, are essential. </Abstract>
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			<Param Name="value">Post-Surgical Adhesion</Param>
			</Object>
			<Object Type="keyword">
			<Param Name="value">Angiotensin Receptor Protein (ARBs)</Param>
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			<Param Name="value">Virtual screening</Param>
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			<Param Name="value">Molecular docking</Param>
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			<Param Name="value">Eprosartan</Param>
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