Official Publication of the National Center for Trauma Research Trauma Monthly 2251-7464 31 1 2026 01 01 Therapeutic Effects of Baneh Gum (Pistacia atlantica Desf.) Extract on Immunological and Histopathological Alterations in an Experimental Model of Ulcerative Colitis 1727 1736 244306 10.30491/tm.2025.527334.1844 EN Majid Mirzaei Nodoushan Applied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical sciences, Tehran, Iran. 0000-0002-8180-1031 Hadi Esmaeili Gouvarchin Ghaleh Applied Virology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical sciences, Tehran, Iran. 0000-0001-8562-2295 Ebrahim Salimi-Sabour Department of Pharmacognosy and Traditional Pharmacy, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran 0000-0002-5315-2126 Mohammad Amrollahi-Sharifabadi Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran. 0000-0002-4458-7689 Javad Raouf Sarshori Department of Anatomical Sciences, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran. 0000-0001-8155-1573 Alireza Shahriary Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. 0000-0003-3240-9591 Journal Article 2025 05 31 <strong>Introduction: </strong>Ulcerative colitis (UC) is a common inflammatory bowel disease that presents significant therapeutic challenges, including adverse drug effects and high treatment costs. Natural-derived agents, such as herbal products, may provide new treatment avenues. This study evaluated the effects of Baneh gum extract (BGE) on immunologic and histopathologic changes in an experimental UC model.<br><strong>Method</strong>: UC was induced using acetic acid in BALB/c mice. Forty mice were randomly divided into four groups (n = 10): the first group served as a control (no treatment); the second and third groups received BGE before (pre-BGE) and after (post-BGE) disease induction, respectively; and the fourth group received mesalazine. After 10 days, the mice were euthanized, and the levels of inflammatory biomarkers, including myeloperoxidase (MPO), nitric oxide, interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), were measured. In addition, histopathologic examinations were performed according to standard protocols.<br><strong>Result: </strong>Our results showed that BGE significantly reduced the production of mediators and inflammatory cytokines, including myeloperoxidase, nitric oxide, IL-1, IL-6, and TNF-α, in an experimental mouse model of acetic acid-induced UC. Histopathological changes were also significantly alleviated by BGE in this model.<br><strong>Conclusion<span dir="RTL" lang="FA">: </span></strong> Our findings support the beneficial use of BGE by attenuating the histopathological and immunological perturbations induced by this experimental animal model of UC. The study highlights the therapeutic promise of BGE, a natural product, in reducing inflammation and tissue damage associated with UC. Further research is needed to establish its clinical efficacy and safety in human patients. https://www.traumamon.com/article_244306_57e358964e8351138a30195503b21886.pdf