Official Publication of the National Center for Trauma Research Trauma Monthly 2251-7464 27 Especial Issue (COVID-19 and Emergency Medicine) 2022 01 01 Assessment of Clinical Characteristics and Outcomes of COVID-19 Patients with Pericardial Effusion 34 40 141499 10.30491/tm.2021.310322.1385 EN Fatemeh Majidi Dr. Shariati Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Majid Faraji The Fellowship of Interventional Cardiology, Dr. Shariati Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Somaye Zamanifard Dr. Shariati Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Farahnaz Nikdoust Dr. Shariati Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Journal Article 2021 10 13 <strong>Introduction:</strong> Evidence shows increased identification of cardiac involvement in patients with COVID-19 with a more critical prognosis. The study aimed to assess the outcomes of COVID-19 patients with pericardial effusion (PE) disease in comparison with a control group.<br /><strong>Methods</strong>: Sixty-One COVID-19 patients who were referred to Shariati hospital in Tehran, Iran, from June 2020 to June 2020 were included. The diagnosis of COVID-19 was according to WHO interim guidance. Eleven cases were with pericardial effusion, and two patients were with a diagnosis of tamponade and pericardial synthesis. Other forty-six Covid-19 cases were as the control group.<br /><strong>Results:</strong> The majority of patients (54.0%) were in the age group of 50–70 years. Also, 62.2% of cases were male. In PE group compared to non-PE group patients had ESR>50 mm/hour [13(86%) vs. 3(66%), P=0.045), hypernatremia [4(26%) vs. 1(2.1%) P=0.007].  In non-PE group compared to PE group patients had PCT>ULN (ug/L) [21(42) vs. 4(26.7), P=0.035].  There was no significant difference between results of lung CT scan (ground glass (GG), pericardial effusion, and pleural effusion) and tachypnea, positive RT-PCR, and lab in the mild PE group compared to the tamponade group. The incidence of shock (or SBP<100) was more in the mild PE group compared to the tamponade group (P=0.048). There was no significant difference in outcomes (all-cause mortality, discharge, ICU admission and duration, shock, MI intubation, and time of admission) between PE and non-PE groups and subgroups of PE (P>0.05).<br /><strong>Conclusion:</strong> The results showed pericardial effusion involvement could happen with COVID-19 patients even without differences in all-cause mortality, discharge, ICU admission and duration, MI, time of admission, and intubation. Although, there was a significant difference in hypernatremia and increased ESR level in the PE group. Also, our data provide some reassurance that PE is not a poor prognostic factor in COVID-19 infection. https://www.traumamon.com/article_141499_1087e89dae1dc1a10ab2ae374ba57353.pdf