Official Publication of the National Center for Trauma Research Trauma Monthly 2251-7464 26 2 2021 04 01 Effect of Dexmedetomidine on Blood Pressure in Hypertension Patients after Emergency Laparotomy for Trauma: A Randomized Double-blind Clinical Trial 94 99 128635 10.30491/tm.2021.274843.1249 EN Reza Movassaghi Gargari Associate Professor of Anesthesia, Medical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran 0000-0003-2777-9133 Hassan Mohammadipour Anvari Associate Professor of Anesthesia, Paramedical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran 0009-0009-9538-3828 Journal Article 2021 02 23 <strong>Background:</strong> Patients with a history of hypertension experience higher postoperative complications than healthy individuals. The frequency of such complications is also higher in emergency patients than elective ones; therefore, it seems that preventive measures are essential.<br /> <strong>Objectives:</strong> The present study aimed at determining the effect of dexmedetomidine on blood pressure in patients with hypertension after emergency laparotomy for trauma.<br /> <strong>Methods:</strong> The present study was a randomized, double-blind clinical trial performed from 2019 to 2020 on patients with a history of hypertension undergoing emergency laparotomy. Patients received the intervention 15 minutes before surgery (the intervention group: intravenous (iv) dexmedetomidine and the control group: normal saline), and the intensity of the pain(VAS), agitation(RASS), and blood pressure were measured and compared at different time points. Data were compared using SPSS software (version 21) by t-test and Chi-square tests considering a significance level of <0.05.<br /> <strong>Results:</strong> There were statistically significant differences between the two groups just after the drug infusion and at all studied time points (p <0.05), so that the intervention group had more stable blood pressure. Pain intensity (p <0.05) and the degree of agitation (p <0.05) in the intervention group were significantly lower than that in the control group at all studied time points.<br /> <strong>Conclusion:</strong> Dexmedetomidine infusion leads to a stabilization of blood pressure during surgery and after surgery, pain relief, and agitation in patients with hypertension undergoing emergency laparotomy for trauma. https://www.traumamon.com/article_128635_6c293b59d5d244bc14164d5815e4f36a.pdf