The role of tissue engineering and regenerative medicine in the treatment of sport injuries a review study

Document Type: Narrative Review


1 Department of Engineering Sciences, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, Iran

2 Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran.

3 Department of Cellular & Physiological Sciences, Faculty of Biology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.



Managing sports injuries is clinically challenging. Although new techniques can delay musculoskeletal deterioration and promoting tissue restoration, but they are not widely used. Thus, there is a critical need to identify these new methods. In recent years, some “tissue engineering” approaches have been developed for improving the regeneration of cartilage by transplanting cells or engineered constructs into injured tissue. The mechanical environment affects the biology of a tissue and is necessary for the development and maintenance of load-bearing tissues. Platelets can be combining with other healing factors as a new therapeutic treatment. Platelet-rich plasmas (PRPs) can be introduced as autologous blood products that may improve wound healing. In this regard, stem cell therapy that focuses on mesenchymal stem cells (MSCs) has been proposed as a new treatment method in sports medicine. MSCs are multipotent which means they have ability to differentiate into other cells, notably osteoblasts, chondrocytes, adipocytes, myoblasts, and fibroblasts, depending on a variety of factors. In summary, recent advances in tissue regeneration provide new perspectives for the use of tissue engineering, microfracture method, mechanical stimuli method, PRP therapy and stem cells therapy to enhance tissue healing after sports injuries.


Articles in Press, Accepted Manuscript
Available Online from 29 May 2020
  • Receive Date: 27 December 2019
  • Revise Date: 13 February 2020
  • Accept Date: 09 February 2020