@article { author = {Rezaeian, Roya and Moslemi, Hamid Reza and Ahmadi Hamedani, Mahmood and Ghaffari Khaligh, Sahar}, title = {Comparison of the effect of Nano Ostrich Eggshell and Hydroxyapatite on Bone Defect Healing in Rat Calvaria}, journal = {Trauma Monthly}, volume = {25}, number = {6}, pages = {236-242}, year = {2020}, publisher = {Official Publication of the National Center for Trauma Research}, issn = {2251-7464}, eissn = {2251-7472}, doi = {10.30491/tm.2021.215315.1055}, abstract = {Background: Fracture healing is important in medicine; thus seeking new techniques with fewer side effects to improve the speed of the healing is prudent. Objectives: This experimental study sought to assess the effect of the nano ostrich eggshell (N-OES) and hydroxyapatite (HA) composite on bone defect healing in rat calvaria. Methods: In this study, a 7-mm bone defect was created in the calvaria of 45 male Sprague–Dawley rats. The animals were randomly divided into three groups, and the defects in each group were filled with N-OES, HA, or as a control group. The animals were euthanized and histological and serological assessments were carried out at 14, 28 and 42 days after the operation. Results: At 14 and 28 days after the operation, in the edges of the defect, there was a significant difference between the treatment and control groups (p ≤ 0.05). However, there were no statistically significant differences between N-OES and HA treatment groups (p > 0.05). At this time, in the center of the defect, there was a statistically significant difference between the N-OES group with HA and control groups (p ≤ 0.05). On day 42, no significant difference in the edges of the defect was observed between all groups. However, there was a statistically significant difference in the center of the defect between the N-OES group with HA and control groups (p ≤ 0.05). Results of the serological assessment indicated that the applied treatments increased the serum levels of alkaline phosphatase. Conclusions: The results of this study indicate the potential efficacy of nano ostrich eggshell as a bone substitute in rat calvaria defects.}, keywords = {Nano ostrich eggshell,Calvarium,Hydroxylapatite,Rat}, url = {https://www.traumamon.com/article_122759.html}, eprint = {https://www.traumamon.com/article_122759_c07965cc9362e70440415f433e0a83ec.pdf} }